Health-Related Quality of Life Outcomes in Meningioma Patients Based upon Tumor Location and Treatment Modality: A Systematic Review and Meta-Analysis

Patients with meningiomas may have reduced health-related quality of life (HRQoL) due to postoperative neurological deficits, cognitive dysfunction, and psychosocial burden. Although advances in surgery radiotherapy improved progression-free survival rates, there is limited evidence regarding treatment outcomes on HRQoL. This review examines HRQoL based tumor location modality. A systematic search PubMed yielded 28 studies 3167 patients. The mean age was 54.27 years most patients were female (70.8%). Approximately 78% located the skull base (10.8% anterior, 23.3% middle, 39.7% posterior fossae). Treatment modalities included craniotomy (73.6%), (11.4%), endoscopic endonasal approach (EEA) (4.0%). Karnofsky Performance Scale (KPS) commonly utilized instrument (27%). Preoperative KPS scores > 80 associated increased occurrence deficits. significant difference found between pre- post-operative for anterior/middle (SBMs) comparison when treated craniotomy. Post-craniotomy SF-36 lower SBMs those anterior middle fossae. Risk factors poor include a high preoperative score experience greater burden